| Title | Developer | Publisher(s) | Exclus. | Japan | Europe | North America |
|---|---|---|---|---|---|---|
| Daigasso! Band-Brothers[25] | Nintendo | Nintendo | Yes | |||
| Danny Phantom: Urban Jungle[8] | THQ | THQ | No | |||
| Dark Reflections[26] | Celisphere Interactive | Celisphere Interactive | ||||
| Dawn speaking of Heroes[27] | TBA | Wicked Studios | ||||
| Days concerning Memories[3] | SNK Playmore | SNK Playmore | ||||
| Dawn concerning War: Squad Command | Relic Entertainment | Relic Entertainment | ||||
| Deal timidity No Deal[3] | Global Star Software EU Mindscape | Destination Software | No | |||
| Death Note: Kira Game[11] | Konami | Konami | ||||
| Death Jr. walk off with the Science Fair about Doom[11] | Foundation 9 | Konami | Yes | |||
| Deep Labyrinth[3] | Interactive Brains | Atlus EU 505 Games AU 505 Games | Yes | |||
| Densetsu proportional representation Stafy 4[28] | TOSE | Nintendo | Yes | |||
| Dementium: The Ward[3] | Renegade Kid | Gamecock | Yes | |||
| Devilish[3] | Starfish | Starfish EU 505 Games NA UFO Interactive | Yes | |||
| Dick McCormack abstract the Abnormally Large Heads[29] | TOSE | At Gun Point | ||||
| Diddy Kong Racing DS[2] | Rare Ltd. | Nintendo | Yes | |||
| Dig Dug: Digging Strike[3] | Namco | Namco EU Atari | Yes | |||
| Digimon World DS[3] | Namco Bandai Games | Namco Bandai Games America JP Bandai | Yes | |||
| Digimon Story: Sunburst/Moonlight/Digimon World Dawn/Dusk[30] | Namco Bandai Games | Namco Bandai Games | Yes | |||
| Dino Master[3] | Creative Office | Majesco Games JP Taito AU Eidos Interactive | Yes | |||
| Disciples II DS[3] | Strategy First | Strategy First | ||||
| Dinosaur Master[31] | Sega | Nintendo | ||||
| Disney Friends[19] | Amaze Entertainment | Disney Interactive | Yes | TBA | October 19, 2007 | February 26, 2008 |
| Disney Princess: Magical Jewels[19] | Disney Interactive | Disney Interactive | Yes | |||
| Disney's American Dragon: Jake Long, Attack speaking of the Dark Dragon[3] | WayForward | Buena Vista Games | Yes | |||
| Disney's Chicken Little: Ace far out Action[3] | Disney Interactive | Buena Vista Games JP Disney Interactive AU Disney Interactive | No | |||
| Disney's Herbie Rescue Rally[3] | Buena Vista | Disney Interactive Studios | ||||
| Disney's Kim Possible: Global Gemini[3] | A2M | Disney Interactive Studios EU Buena Vista Games | Yes | |||
| Disney's Kim Possible: Kimmunicator[3] | Artificial Mind | Buena Vista Games | Yes | |||
| Disney's Meet the Robinsons[19] | Disney Interactive Studios | Disney Interactive Studios | No | |||
| Disney's The Little Mermaid: Ariel's Undersea Adventure[3] | Gorilla Systems | Disney Vista Games JP Disney Interactive Studios | ||||
| DK Jungle Climber[2] | Paon | Nintendo | Yes | |||
| Dogz[10] | MTO | Ubisoft AU MTO | ||||
| Dokidoki Majo Saiban[3] | SNK Playmore | SNK Playmore | Yes | |||
| Dragon Ball Z: Harukanaru Densetsu[3] | Bec | Namco Bandai Games NA Atari AU Atari | Yes | |||
| Dragon Ball Z: Supersonic Warriors 2[3] | Banpresto | Atari JP Bandai | Yes | |||
| Dragon Booster[11] | KCE Hawaii | Konami | ||||
| Dragon Quest IV[3] | ArtePiazza | Square Enix | No | |||
| Dragon Quest V | ArtePiazza | Square Enix | No | |||
| Dragon Quest VI | ArtePiazza | Square Enix | No | |||
| Dragon Quest IX Hoshizora aye Mamoribito[3] | Level 5 | Square Enix | Yes | |||
| Dragon Quest Heroes: Rocket Slime[3] | TOSE/Square Enix | Square Enix | Yes | |||
| Dragon Quest Monsters: Joker[32] | Square Enix | Square Enix | Yes | |||
| Drawn as far as Life[8] | 5th Cell | THQ | No | |||
| DS Easy Dictionary[33] | Nintendo | Nintendo | Yes | |||
| Dungeon Explorer: Warriors about Ancient Arts[3] | Hudson Soft | Nintendo | Yes | |||
| Dust & Shadows[34] | Neko Entertainment | Neko Entertainment | ||||
| Dynasty Warriors DS[3] | Koei | Koei | Yes |