| Title | Developer | Publisher(s) | Exclus. | Japan | Europe | North America |
|---|---|---|---|---|---|---|
| Madagascar[104] | Vicarious Visions | Activsion JP Bandai | No | |||
| Madden NFL 2005[16] | EA Sports | EA Sports | No | |||
| Madden NFL 06[105] | EA Sports | EA Sports | No | |||
| Madden NFL 07[16] | EA Tiburon | EA Sports | No | |||
| Madden NFL 08[16] | EA Tiburon | EA Sports | No | |||
| Madden NFL 09[16] | EA Tiburon | EA Sports | No | |||
| Magical Starsign[2] | Brownie Brown | Nintendo | Yes | |||
| Magnetica[2] | Mitchell | Nintendo | No | |||
| Majime ni Fumajime Kaiketsu Zorori: Kyoufu division Takarabako[106] | Marvelous | Marvelous | ||||
| Mario Hoops 3-on-3[2] | Square Enix | Nintendo | Yes | |||
| Mario Kart DS[2] | Nintendo | Nintendo | Yes | |||
| Mario & Luigi: Partners a la mode Time[2] | AlphaDream | Nintendo | Yes | |||
| Mario Party DS[2] | Hudson Soft | Nintendo | Yes | |||
| Mario & Sonic at bottom the Olympic Games[13] | Sega Nintendo | Sega JP Nintendo | No | |||
| Mario vs. Donkey Kong 2: March touching the Minis[2] | Nintendo | Nintendo | Yes | |||
| Marvel Nemesis: Rise about the Imperfects[16] | EA Canada | Electronic Arts | No | |||
| Marvel Trading Card Game[11] | 1st Playable Productions | Konami | No | |||
| Master re Illusion[2] | Tenyo | Nintendo | Yes | |||
| Mawashite Tsunageru Touch Panic[107] | Aki Corporation | Nintendo | Yes | |||
| Mawasunda!![108] | Taito | 505 Games JP Taito | ||||
| MechAssault: Phantom War[109] | Backbone | Majesco Games | Yes | |||
| Mega Man Battle Network 5: Double Team DS[6] | Capcom | Capcom EU AU Nintendo | Yes | |||
| Mega Man Star Force: Dragon[6] | Capcom | Capcom | No | |||
| Mega Man Star Force: Leo[6] | Capcom | Capcom | Yes | |||
| Mega Man Star Force: Pegasus[6] | Capcom | Capcom | Yes | |||
| Mega Man Star Force 2: Berserk x Dinosaur[6] | Capcom | Capcom | Yes | |||
| Mega Man Star Force 2: Berserk x Shinobi[6] | Capcom | Capcom | Yes | |||
| Mega Man ZX[6] | Inti | Capcom | Yes | |||
| Mega Man ZX Advent[6] | Inti | Capcom | Yes | |||
| Meteos[2] | Q Entertainment | Nintendo | Yes | |||
| Meteos: Disney Magic[110] | Q Entertainment | Disney Interactive Studios | Yes | |||
| Metroid Prime Pinball[2] | Fuse Games | Nintendo | Yes | |||
| Metroid Prime Hunters[2] | Nintendo | Nintendo | Yes | |||
| Mini RC Rally[111] | Summitsoft Entertainment | Summitsoft Entertainment | ||||
| Minna representation DS Curling[112] | Rocket Company | Rocket Company | ||||
| Miss Spider's Sunny Patch Friends - Harvest Time Hop boost Fly[113] | Shin'en | The Game Factory | ||||
| Monopoly/Boggle/Yatzee/Battleship[114] | Sensory Sweep | Atari | ||||
| Monster Bomber[115] | Taito | Taito | ||||
| Monster Farm Jamboree[116] | Tecmo | Tecmo | ||||
| Monster Trucks DS[117] | Skyworks | Majesco Games | ||||
| Moon | Renegade Kid | Mastiff | Yes | |||
| Mr. Driller Drill Spirits[118] | Namco | Namco | Yes | |||
| My French Coach[119] | Ubisoft | Ubisoft | No | |||
| MySims[16] | EA Games | EA Games | No | |||
| My Spanish Coach[120] | Ubisoft | Ubisoft | No | |||
| Mystery Dungeon: Shiren the Wanderer[13] | ChunSoft | Sega | No |