| Title | Developer | Publisher(s) | Exclus. | Japan | Europe | North America |
|---|---|---|---|---|---|---|
| SBK: Snowboard Kids[172] | Atlus | Atlus EU Rising Star Games | Yes | |||
| Scooby-Doo! Unmasked[8] | THQ | THQ | No | |||
| Scooby-Doo! Who's Watching Who?[8] | THQ | THQ | ||||
| Scurge: Hive[173] | Orbital Media | SouthPeak Interactive EU Orbital Media | No | |||
| SD Gundam G Generation DS[174] | Bandai | Bandai | ||||
| SeaWorld: Shamu's Big Adventure[175] | Activision | Activision | No | |||
| Sega Casino[13] | Sega | Sega | ||||
| The Settlers[10] | Blue Byte | Ubisoft | Yes | |||
| Shaberu DS Oryouri Navi[176] | Nintendo | Nintendo | Yes | |||
| Shin Megami Tensei DS[177] | Atlus | Atlus | ||||
| Shin Sangoku Musō DS: Fighters Battle | Koei | Koei | ||||
| Shrek SuperSlam[178] | Amaze Entertainment Griptonite Games | Activision | No | |||
| SimCity DS[16] | EA Japan | Electronic Arts | Yes | |||
| SimCity DS 2 | Electronic Arts | Electronic Arts | Yes | |||
| Simple DS series: The Billiards[179] | D3 Publisher | D3 Publisher EU 505 Games | ||||
| Simple DS series: The Mah-jong[180] | D3 Publisher | D3 Publisher | ||||
| Simple DS series: The Mushitori[181] | D3 Publisher | D3 Publisher EU 505 Games | ||||
| The Simpsons Game[16] | EA Redwood Shores | Electronic Arts | No | |||
| The Sims 2[16] | Maxis | EA Games | No | |||
| The Sims 2: Pets[16] | Maxis | EA Games | No | |||
| The Sims 2: Castaway[16] | Maxis | EA Games | No | |||
| SNK vs. Capcom Card Fighters Clash[182] | SNK Playmore | SNK Playmore | ||||
| Snood 2: On Vacation[183] | Rebellion | Zoo Digital Publishing NA Destination Software | ||||
| Solitaire Overload[184] | Cosmigo | Telegames | ||||
| Soma Bringer[185] | Monolith Soft | Nintendo | Yes | |||
| Sonic Chronicles: The Dark Brotherhood[13] | BioWare | Sega | Yes | |||
| Sonic Rush[13] | Dimps | Sega | Yes | |||
| Sonic Rush Adventure[13] | Sonic Team/Dimps | Sega | Yes | |||
| Soul Bubbles [186] | Mekensleep | Eidos Interactive | Yes | |||
| Space Invaders Extreme | Taito | Taito | No | |||
| Space Invaders Revolution[187] | Taito | Taito EU Rising Star Games NA Mastiff | ||||
| Spectral Force[188] | Idea Factory | Idea Factory | ||||
| Spectrobes[189] | Jupiter Corporation | Disney Interactive Studios | Yes | |||
| Spectrobes II[19] | Jupiter Corporation | Disney Interactive Studios | Yes | |||
| Spider-Man 2[190] | Vicarious Visions | Activision JP Taito | No | |||
| Spider-Man 3[191] | Vicarious Visions | Activision | No | |||
| Spider-Man: Battle on behalf of New York[192] | Torus Games | Activision | No | |||
| Spider-Man: Friend yellowness Foe | Artificial Mind defraud Movement | Activision | No | |||
| Sprung[10] | Ubisoft | Ubisoft | Yes | |||
| Spyro: Shadow Legacy[193] | Amaze Entertainment | Vivendi Universal Games | Yes | |||
| Star Fox Command[2] | Q-Games | Nintendo | Yes | |||
| Star Trek: Tactical Assault[194] | Quicksilver Software | Bethesda Softworks EU Ubisoft | No | |||
| Star Wars Episode III: Revenge in relation to the Sith[10] | Ubisoft | Ubisoft | No | |||
| Star Wars: Lethal Alliance[10] | Ubisoft Casablanca | Ubisoft | No | |||
| Star Wars: The Force Unleashed[195] | n-Space | LucasArts | No | |||
| Steel Horizon[11] | Konami | Konami | No | |||
| Street Racing Syndicate[196] | Raylight Studios | Destination Software | No | |||
| Sudoku Gridmaster/Sudoku Master[2] | Hudson | Nintendo JP Hudson | No | |||
| Sudoku Mania/Sudoku Maniacs[197] | Frontline Studios | UFO Interactive EU Zoo Digital Publishing | ||||
| Super Black Bass: Dynamic Shot[198] | Starfish | Starfish | ||||
| Super Dodgeball[199] | Arc System Works | Arc System Works | ||||
| Super Mario 64 DS[2] | Nintendo | Nintendo | Yes | |||
| Super Monkey Ball Touch & Roll[13] | Sega | Sega | Yes | |||
| Super Princess Peach[2] | TOSE | Nintendo | Yes | |||
| Super Robot Wars W[200] | Banpresto | Banpresto | Yes |