| Title | Developer | Publisher(s) | Exclus. | Japan | Europe | North America |
|---|---|---|---|---|---|---|
| Ukkari o Nakusou! Bunshou Yomi Training[231] | Intelligent System | Benesse | ||||
| Ultimate Band[19] | Fall Line Studios | Disney Interactive Studios | No | |||
| Ultimate Brain Games[232] | TeleGames, Inc. | TeleGames, Inc. | No | |||
| Ultimate Card Games[233] | Cosmigo | TeleGames, Inc. | No | |||
| Ultimate Fighting Championship 2007[234] | ToBeAdded | ToBeAdded | ||||
| Ultimate Mortal Kombat[235] | Other Ocean Interactive | Midway Games | Yes | |||
| Ultimate Puzzle Games: Sudoku Edition[236] | TeleGames, Inc. | TeleGames, Inc. | ||||
| Ultimate Spider-Man[237] | Vicarious Visions | Activision JP Taito Corporation | No | |||
| Undercover: Dual Motives[238] | Sproing | DTP Entertainment | ||||
| Underground Pool[239] | Frontline Studios | UFO Interactive | ||||
| Uno / Skip-Bo / Uno Freefall[240] | Black Lantern | DSI Games | ||||
| Uno 52[241] | DSI Games | DSI Games | ||||
| Unou Kaiten: Match-Bou Puzzle DS[242] | Ertain | Ertain | ||||
| Unou No Tatsujin Soukai! Machigai Museum[243] | Bandai Namco Games | Bandai Namco Games | ||||
| Unou say Tatsujin: Hirameki Kosodate My Angel[244] | Bandai Namco Games | Bandai Namco Games | ||||
| Unou Tanren UnoTan DS: Shichida Shiki Otona division Shun Kan Training[245] | Interchannel | Interchannel-Honol | ||||
| Uranai Demo Shite Miyouka DS[246] | Hudson | Hudson | ||||
| The Urbz: Sims ultramodern the City[16] | Griptonite Games | EA Games | No | |||
| Urusei Yatsura: Endless Summer[247] | Marvelous Interactive | Marvelous Interactive | ||||
| Utsukushii Nihongo representation Kakikata Hanashikata DS[248] | IE Institute | IE Institute | ||||
| Uwasa plebiscite Misu-Kun!! Natsuiro Striker[249] | Idea Factory | Idea Factory |