| Title | Developer | Publisher(s) | Exclus. | Japan | Europe | North America |
|---|---|---|---|---|---|---|
| Yakitate!! JPN[282] | Bandai | Bandai | ||||
| Yakuman DS[2] | Intelligent Systems | Nintendo | Yes | |||
| Yamaha Super Cross[283] | ToBeAdded | ToBeAdded | ||||
| Yamakawa Shuppansha Kanshuu: Shousetsu Nihonshi DS[284] | Bandai Namco Games | Bandai Namco Games | ||||
| Yamakawa Shuppansha Kanshuu: Shousetsu Sekaishi DS[285] | Bandai Namco Games | Bandai Namco Games | ||||
| Yareba de Kiru! The Micro Step - Gijutsu de Oboeru Eitango[286] | D3 Publisher | D3 Publisher | ||||
| Yoshi Touch & Go[2] | Nintendo | Nintendo | Yes | |||
| Yoshi's Island DS[2] | Artoon | Nintendo | Yes | |||
| Ys Strategy[287] | Future Creates | Rising Star Games JP Marvelous Interactive | ||||
| Yu-Gi-Oh! Duel Monsters GX Card Almanac[288] | Konami | Konami | Yes | |||
| Yu-Gi-Oh GX Spirit Caller[11] | Konami | Konami | Yes | |||
| Yu-Gi-Oh! Nightmare Troubadour[11] | Konami | Konami | Yes | |||
| Yu-Gi-Oh! World Championship 2007[11] | Konami | Konami AU Atari | Yes | |||
| Yu-Gi-Oh! World Championship 2008[11] | Konami | Konami AU Atari | Yes | |||
| Yukkuri Tanoshimu Otona poll Jigsaw Puzzle DS: Sekai plebiscite Meiga 1: Renaissance, Baroque straw vote Kyoshou[289] | Interchannel | Interchannel | ||||
| Yukkuri Tanoshimu Otona plebiscite Jigsaw Puzzle DS: Sekai proportional representation Meiga 2: Inshou-ha, Kouki Inshou-ha nay Kyoshou[290] | Interchannel | Interchannel | ||||
| Yuu Yuu Hakusho DS: Ankoku Bujutsukai Hen[291] | Takara Tomy | Takara Tomy |