| Title | Developer | Publisher(s) | Exclus. | Japan | Europe | North America |
|---|---|---|---|---|---|---|
| Zaidan Houjin Nippon Kanji Nouryoku Kentei Kounin: KanKen DS[292] | Rocket Company | Rocket Company | ||||
| Zendoku[293] | Zoonami | Eidos Interactive | No | |||
| Zenmai Zamurai[294] | Genki | Genki | ||||
| Zettai Onkan Master[295] | Hudson | Hudson | ||||
| Zettai Onkan Otoda Master[296] | ToBeAdded | Hudson | ||||
| Zettai Onkan Training DS[297] | Success | Success | ||||
| Zettai Zetsumei Dangerous Jiisan DS: Dangerous Sensation[298] | Kids Station | Kids Station | ||||
| Zettai Zetsumei Dangerous Ojiisan[299] | Kids Station | Kids Station | ||||
| Zoey 101: Field Trip Fiasco[8] | THQ | THQ | ||||
| Zoids Battle Colosseum[300] | Tomy | Tomy | ||||
| Zoids Dash[301] | Tomy | Tomy | ||||
| Zoids Saga DS[302] | Tomy | Tomy | No | |||
| The Zokusha Kids[303] | ToBeAdded | D3 Publisher | ||||
| Zoo Hospital[304] | Majesco | Torus Games | ||||
| Zoo Keeper[305] | Success | Ignition Entertainment | No | |||
| Zoo Tycoon DS[8] | Blue Fang Games Microsoft Game Studios | THQ JP Sega | Yes | |||
| Zoo Tycoon 2 DS[8] | Blue Fang Games THQ | THQ | Yes |